CEEO - LABORATORY 32

 

CENTRO DE ESTUDOS EM ESTRESSE OXIDATIVO
(CENTER OF STUDIES ON OXIDATIVE STRESS)

José Cláudio Fonseca Moreira

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Principal Investigator

BSc (Hons) in Biological Sciences - Molecular Biology by the Universidade de Brasília (1985), MSc in Biological Sciences (Biochemistry) by the Federal University of Rio Grande do Sul (UFRGS – 1988) and PhD in  Sciences (Biochemistry) by the Federal University of Paraná (1995). Dr. Moreira is currently a professor at the Biochemistry Department of UFRGS. He has experience in the field of biochemistry, focused on systems biology, acting mainly in the following areas: oxidative stress, retinol (vitamin A), cellular signaling through reactive species, the search for new anti-oxidants, and neurodegenerative and psychiatric disorders.
Curriculumhttp://lattes.cnpq.br/0710138621945711

Research lines

Title: REACTIVE SPECIES AND THEIR EFFECTS ON BIOLOGICAL SYSTEMS


Description: evaluation of the role of reactive species as signaling molecules of the main biochemical processes of biological systems, both in physiological and pathological processes; as well as the investigation of their role in cellular differentiation and growth. Search and evaluation of natural or synthetic compounds with active redox properties. 
 

 

Title: BIOINFORMATICS AND SYSTEMS BIOLOGY APPLIED TO BIOCHEMISTRY
 

Description: application of bioinformatics and systems biology tools in solving biochemical questions. The development of new software for the analysis of gene expression and proteomics databases.

Title: BIOPROSPECTING THE BIOACTIVE PROPERTIES OF DERIVATIVES OF NATURAL PRODUCTS 

Description: investigation of bioactive properties with antioxidant potential in products derived from  flora and fauna.

Daniel Pens Gelain

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Professor

Biologist, MSc and PhD in Biochemistry by the Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil). Professor in Universidade Federal de Sergipe (Aracaju, Brazil) in 2009-2010 and currently Professor of the Department of Biochemistry in the Institute of Basic Sciences of Health of Universidade Federal do Rio Grande do Sul (UFRGS) since 2010. Lecturer of basic and advanced biochemistry classes for Biological Sciences, Biotechnology and Biomedical Sciences courses, conducts research on oxidative stress and redox-sensitive modulation of neurodegeneration, neuroinflammation and neurodifferentiation. Supervisor of MSc and PhD in Biochemistry, Molecular and Cell Biology.
 
Curriculum Vitaehttp://lattes.cnpq.br/8231221319859774

Research lines

Title: REDOX MODULATION OF NEURODIFFERENTIATION

Description: to establish the role of reactive species (free radicals) and oxidative stress in the process of neuronal differentiation, through the study of how signaling pathways and transcription factors that influence neurodifferentiation in cultured cancer cells and neural stem cells are affected by different redox  states.

Title: RAGE AS THE LINK BETWEEN SYSTEMIC INFLAMMATION AND NEURODEGENERATION

Description: the course of neurodegenerative diseases such as Parkinson’s disease (our main focus) are strongly influenced by inflammatory conditions, and neuroinflammation itself is an important part of the disease. By using different in vivo, in vitro and systems biology approaches, we have been elucidating the role of the Receptor for Advanced Glycation End Products (RAGE) as an essential factor connecting early systemic inflammatory episodes to the development of neurodegeneration at long-term.

Title: BIOLOGICAL ACTIONS OF BRAZILIAN NATURAL PRODUCTS WITH NEUROPROTECTIVE POTENTIAL

Description: Brazil bears a huge biological diversity along its territory and coast, which is responsible for an enormous potential for the discovery of new biomolecules with novel pharmacological applications. In collaboration with research groups from different parts of Brazil, we conduct research on the evaluation of the potential antioxidant and neuroprotective actions of natural products.